HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → HCID 19763587, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | HCID 800521 | — |
| Reactant | HCID 19763538 | HCID 19763538 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 19763587 | HCID 19763587 | — |
Reaction Steps
A 1.0 g portion of 3-(1-methyl-1H-pyrazol-3-yl)piperazine and 508 mg of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid were dissolved in 5 ml of pyridine and heated at 85°-95° C. for 18 hours, in a pressure bottle which had been evacuated and filled with argon. Methanol was added and the solid collected, giving 610 mg of 1-ethyl-6-fluoro-1,4-dihydro-7-[3-(1-methyl-1H-pyrazol-3-yl)-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05210193 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-d8edb6c6c3b2478686ffd572bb122c21 |
| Source note | uspto-grants-1993_05 |