2-(1,1-Difluoroethyl)pyrazine → 2-(1,1-Difluoroethyl)piperazine

HRID 248532Notes

Reaction equation

HRID 248532 reaction equation
[F:1][C:2]([C:5]1[CH:6]=[N:7][CH:8]=[CH:9][N:10]=1)([F:4])[CH3:3].[H][H]>CO.[Pt]=O>[F:1][C:2]([CH:5]1[NH:10][CH2:9][CH2:8][NH:7][CH2:6]1)([F:4])[CH3:3]

Participants

5

Reactant 2

HCID 197635642-(1,1-Difluoroethyl)pyrazineHCID 178418361HCID 178418361, compound

Product 1

HCID 197635812-(1,1-Difluoroethyl)piperazine

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

A 4.3 g portion of 3-(1,1-difluoroethyl)pyrazine in 25 ml of methanol was reduced with 50 psi hydrogen and 750 mg of platinum oxide at 20° C. for 5 hours. The resulting oil was purified by chromatography, giving about 700 mg of 3-(1,1-difluoroethyl)piperazine.

Workup

  1. customThe resulting oil was purified by chromatography

Sources & evidence

ORD record
ord-61ee99b124134599a18fa13e6ec7af1c
Source dataset
uspto-grants-1993_05
Patent number
US05210193

Reaction notes

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