HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aluminium lithium hydride → 1-Methyl-3-(thiophen-3-yl)piperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Reactant | HCID 85536114 | HCID 85536114 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-Methyl-3-(thiophen-3-yl)piperazine | HCID 19763536 | 93.4% |
Reaction Steps
A solution of 1.20 g of 3-(3-thienyl)-1-piperazine carboxylic acid, ethyl ester in 100 ml of ether was added to a suspension of 380 mg of lithium aluminum hydride in 50 ml of ether. The mixture was refluxed for 12 hours and the product recovered, giving 850 mg of 4-methyl-2-(3-thienyl)piperazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05210193 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-271a57d9d7e84be39fb2694ca37e1fa0 |
| Source note | uspto-grants-1993_05 |