Water → Ethyl 2,4,5-trifluorobenzoylacetate

HRID 248537Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 248537
[F:1][C:2]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:3]=1[C:4]([CH:6](C(OCC)=O)[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].O>O1CCOCC1>[F:1][C:2]1[CH:20]=[C:19]([F:21])[C:18]([F:22])=[CH:17][C:3]=1[C:4](=[O:5])[CH2:6][C:7]([O:9][CH2:10][CH3:11])=[O:8]

Komponenten

4

Edukt 2

HCID 962WaterHCID 14839349HCID 14839349, Verbindung

Produkt 1

HCID 2758933Ethyl 2,4,5-trifluorobenzoylacetateAusbeute 58,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
102 °C

Versuchsvorschrift

A solution of 23.8 g of (2,4,5-trifluorobenzoyl)propanedioic acid, diethyl ester, 2.7 ml of water and 740 ml of p-dioxane was placed in an oil bath and stirred at 102° C. for 7 hours. The solution was then evaporated to dryness, heptane was added and the mixture refrigerated overnight. The resulting crystals were collected, washed with 10 ml of cold heptane and dried, giving 10.8 g of 2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester.

Aufarbeitung

  1. customThe solution was then evaporated to dryness, heptane
  2. additionwas added
  3. customthe mixture refrigerated overnight
  4. customThe resulting crystals were collected
  5. washwashed with 10 ml of cold heptane
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-46d833d617034691ae51471592caf52c
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05210193

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