Acetic Anhydride → Ethyl 3-(2,4,5-trifluorophenyl)-3-oxo-2-(ethoxymethylene)propanoate
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([F:9])=[CH:4][C:3]=1[C:10](=[O:17])[CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13].[CH2:18]([O:20][CH:21](OCC)OCC)[CH3:19].C(OC(=O)C)(=O)C>>[CH2:18]([O:20][CH:21]=[C:11]([C:10](=[O:17])[C:3]1[CH:4]=[C:5]([F:9])[C:6]([F:8])=[CH:7][C:2]=1[F:1])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[CH3:19]Participants
4
Conditions
- Temperature
- 115 °C
Procedure
A solution of 7.88 g of 2,4,5-trifluoro-β-oxo-benzenepropanoic acid, ethyl ester, 8.15 ml of 98% triethoxymethane and 7.5 ml of acetic anhydride in a 50 ml of flask was connected through a short distillation head to a 160 mm vacuum source and heated at 115° C. for 3 hours. The solution was then evaporated in vacuo at 45° C. giving 9.67 g of α-(ethoxymethylene)-2,4,5-trifluoro-β-oxobenzenepropanoic acid, ethyl ester as a yellow oil.
Workup
- customThe solution was then evaporated in vacuo at 45° C.
Sources & evidence
- ORD record
- ord-f9743d5bb85c4b83987928708d3c358f
- Source dataset
- uspto-grants-1993_05
- Patent number
- US05210193
Reaction notes
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