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HRID248539

反应详情

EQUATION

反应方程式

HRID 248539 的结构方程式

REACTANTS

反应物

1
结构：CCOC(=O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O
HCID9817544

Ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate

C15H13F2NO3

PRODUCTS

生成物

1
结构：O=C(O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O
HCID5210422

1-Cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

C13H9F2NO3

收率 95.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=S(=O)(O)O
溶剂HCID1118

Sulfuric acid

H2O4S

CONDITIONS

反应条件

温度
100 °C

PROCEDURE

实验过程

A suspension of 7.85 g of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, ethyl ester in 220 ml of 2N sulfuric acid was heated at 100° C. overnight, then cooled in an ice bath. The solid was collected, washed with water and dried, giving 6.81 g of the desired compound, mp 292°-293° C.

WORKUP

后处理

  1. temperaturecooled in an ice bath
  2. customThe solid was collected
  3. washwashed with water
  4. customdried