HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 248540Generated: October 30, 2026
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid → 1-Cyclopropyl-6-fluoro-7-[3-(fluoromethyl)-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
https://huagongshe.com/reaction/248540
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid | HCID 5210422 | — |
| Reactant | HCID 14479501 | HCID 14479501 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-Cyclopropyl-6-fluoro-7-[3-(fluoromethyl)-1-piperazinyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 14479503 | 36.1% |
Reaction Steps
A suspension of 530.4 mg of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, 590.7 mg of 2-(fluoromethyl)piperazine and 2 ml of pyridine was heated at 115° C. for 30 minutes, then filtered and the filtrate refrigerated overnight. The resulting crystals were collected, washed with water, ether and dried, giving 262 mg of the desired compound as light yellow crystals, mp 202°-203° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05210193 |
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| Source dataset | uspto-grants-1993_05 |
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| ORD ID | ord-0c45423e79f546f29b44b0a138879586 |
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| Source note | uspto-grants-1993_05 |
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