Dimethylformamide → HCID 20095713, compound

Participants

Reaction Conditions

Reaction Steps

43.6 g of 5-bromo-2,4-diethoxy-6-methyl-1-methoxymethyloxybenzene prepared in Referential Example 8 was dissolved in 220 ml of THF, and 100 ml of n-buthyllithium (1.6 M n-hexane solution) was dropwise added thereto at -70° C. The mixture was stirred at -40° C. for 30 min, and 11.9 g of dimethylformamide was dropwise added thereto. The temperature of the reaction mixture was returned to room temperature, and an aqueous ammonium chloride solution was added thereto,-followed by extracting with ethyl acetate. The organic phase was washed with water, dried, concentrated and purified by silica gel column chromatography (eluent; n-hexane : ethyl acetate=90 : 10) to prepare 19.2 g of the product compound as a colorless oleaginous substance.

Provenance & Evidence