Acetic Anhydride → HCID 178474539, compound

HRID 24859Notes

Reaction equation

HRID 24859 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]/[C:17](=[C:26]2\[C:27](=[O:38])[NH:28][C:29]3[C:34]\2=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[CH:31][CH:30]=3)/[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][NH2:25])=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:39](OC(=O)C)(=[O:41])[CH3:40]>O1CCOCC1>[C:1]([O:5][C:6]([NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]/[C:17](=[C:26]2\[C:27](=[O:38])[NH:28][C:29]3[C:34]\2=[CH:33][C:32]([N+:35]([O-:37])=[O:36])=[CH:31][CH:30]=3)/[C:18]2[CH:23]=[CH:22][C:21]([CH2:24][NH:25][C:39](=[O:41])[CH3:40])=[CH:20][CH:19]=2)=[CH:12][CH:11]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178453077HCID 178453077, compound

Product 1

HCID 178474539HCID 178474539, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared analogously to Example 31 from (Z)-3-[1-(4-tert.butoxycarbonylaminomethyl-phenylamino)-1-(4-aminomethyl-phenyl)-methylidene]-5-nitro-2-indolinone and acetic anhydride in dioxane.

Sources & evidence

ORD record
ord-6872c6d653db415e8f1de117a3338e29
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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