HCID 19009912, compound → 4-(Aminomethyl)cyclohexan-1-amine

HRID 248606Notes

Reaction equation

HRID 248606 reaction equation
[N:1]([CH:4]1[CH2:9][CH2:8][CH2:7][CH:6]([CH2:10][N:11]=C=O)[CH2:5]1)=C=O.[N:14]([CH:17]1[CH2:22][CH2:21][CH:20]([CH2:23][N:24]=C=O)[CH2:19][CH2:18]1)=C=O>>[NH2:1][CH:4]1[CH2:9][CH2:8][CH2:7][CH:6]([CH2:10][NH2:11])[CH2:5]1.[NH2:14][CH:17]1[CH2:22][CH2:21][CH:20]([CH2:23][NH2:24])[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 19009912HCID 19009912, compoundHCID 19385891HCID 19385891, compound

Product 2

HCID 4450214-(Aminomethyl)cyclohexan-1-amineHCID 220581323-(Aminomethyl)cyclohexan-1-amine

Procedure

To a flask similar to that used in Example 12, there were added 10.0 g (0.056 mole) of a mixture of (3-isocyanatocyclohexyl) methylisocyanate and (4-isocyanatocyclohexyl)methylisocyanate (obtained by phosgenation of a mixture of (3-aminocyclohexyl) methylamine and (4-aminocyclohexyl)methylamine; hereunder referred to as "ICMI") and 3.3 g of butyl acetate to dissolve the former in the latter and the temperature was adjusted to 25° C. with stirring in a nitrogen gas blanket. 0.4 g (3.2×10-4 mole) of a catalyst B (prepared in the same manner as in Example 12) was added thereto, then the flask was externally warmed or cooled to control the temperature of the solution to 60° C.

Workup

  1. customTo a flask similar to that used in Example 12, there

Sources & evidence

ORD record
ord-cc68d92d86584aaf96c7d02640c1e83a
Source dataset
uspto-grants-1993_05
Patent number
US05210286

Reaction notes

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