HRID24863

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7918

Acetic anhydride

C4H6O3

$结构：CC(C)(C)OC(=O)NCCc1ccc(N/C(=C2\C(=O)Nc3ccc([N+](=O)[O-])cc32)c2ccc(CN)cc2)cc1$

HCID178453290

未命名化合物

PRODUCTS

生成物

结构：CC(=O)NCc1ccc(/C(Nc2ccc(CCNC(=O)OC(C)(C)C)cc2)=C2/C(=O)Nc3ccc([N+](=O)[O-])cc32)cc1

HCID178474537

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

Prepared analogously to Example 31 from (Z)-3-{1-[4-(2-tert.butoxycarbonylamino-ethyl)-phenylamino]-1-(4-aminomethyl-phenyl)-methylidene}-5-nitro-2-indolinone and acetic anhydride in dioxane.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f50174aec6c74af1a4e9dc3f3c7db749
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17]/[C:18](=[C:27]2\[C:28](=[O:39])[NH:29][C:30]3[C:35]\2=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][CH:31]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][NH2:26])=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:40](OC(=O)C)(=[O:42])[CH3:41]>O1CCOCC1>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH:17]/[C:18](=[C:27]2\[C:28](=[O:39])[NH:29][C:30]3[C:35]\2=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][CH:31]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][NH:26][C:40](=[O:42])[CH3:41])=[CH:21][CH:20]=2)=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]