Acetic Anhydride → HCID 178474537, compound

HRID 24863Notes

Reaction equation

HRID 24863 reaction equation
[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][C:14]([NH:17]/[C:18](=[C:27]2\[C:28](=[O:39])[NH:29][C:30]3[C:35]\2=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][CH:31]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][NH2:26])=[CH:21][CH:20]=2)=[CH:13][CH:12]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:40](OC(=O)C)(=[O:42])[CH3:41]>O1CCOCC1>[C:1]([O:5][C:6]([NH:8][CH2:9][CH2:10][C:11]1[CH:12]=[CH:13][C:14]([NH:17]/[C:18](=[C:27]2\[C:28](=[O:39])[NH:29][C:30]3[C:35]\2=[CH:34][C:33]([N+:36]([O-:38])=[O:37])=[CH:32][CH:31]=3)/[C:19]2[CH:24]=[CH:23][C:22]([CH2:25][NH:26][C:40](=[O:42])[CH3:41])=[CH:21][CH:20]=2)=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 178453290HCID 178453290, compound

Product 1

HCID 178474537HCID 178474537, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Prepared analogously to Example 31 from (Z)-3-{1-[4-(2-tert.butoxycarbonylamino-ethyl)-phenylamino]-1-(4-aminomethyl-phenyl)-methylidene}-5-nitro-2-indolinone and acetic anhydride in dioxane.

Sources & evidence

ORD record
ord-f50174aec6c74af1a4e9dc3f3c7db749
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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