Ethyl 2-Butyl-4-(1H-pyrrol-1-yl)imidazole-5-carboxylate → 2-Butyl-5-(hydroxymethyl)-4-(1H-pyrrol-1-yl)imidazole

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Reaction Steps

A solution of ethyl 2-butyl-4-(1H-pyrrol-1-yl)imidazol-5-carboxylate (Example 21, 0.5 g) in tetrahydrofuran (15 mL) was treated with a 1M solution of LiAlH4 in ether (2.1 mL). The reaction was stirred overnight at room temperature then quenched by addition of saturated aqueous (NH4)2SO4. The resulting suspension was extracted three times with ethyl acetate and the combined organic layers were dried over anhydrous magnesium sulfate and evaporated to afford the title compound as an off-white solid MS (DEI) 205 (m)

Provenance & Evidence