Triethylamine → 3-[4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]propionic Acid Ethyl Ester

HRID 248738Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 248738
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][S:9]([C:12]2[CH:20]=[CH:19][CH:18]=[CH:17][C:13]=2C(O)=O)(=[O:11])=[O:10])=[CH:4][C:3]=1[C:21]([F:24])([F:23])[F:22].Cl.[CH2:26]([O:28][C:29](=[O:33])[CH2:30][CH2:31][NH2:32])[CH3:27].O.[OH:35][C:36]1C2N=NNC=2C=CC=1.C(N(CC)CC)C.C1(N=C=NC2CCCCC2)CCCCC1>>[CH2:26]([O:28][C:29](=[O:33])[CH2:30][CH2:31][NH:32][C:36](=[O:35])[C:18]1[CH:17]=[CH:13][C:12]([S:9](=[O:10])(=[O:11])[NH:8][C:5]2[CH:6]=[CH:7][C:2]([F:1])=[C:3]([C:21]([F:24])([F:23])[F:22])[CH:4]=2)=[CH:20][CH:19]=1)[CH3:27]

Komponenten

6

Edukt 5

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 458475beta-Alanine, ethyl ester, hydrochlorideHCID 197640052-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acidHCID 178526939HCID 178526939, Verbindung

Produkt 1

HCID 540932793-[4-[N-(4-Fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoylamino]propionic Acid Ethyl Ester

Versuchsvorschrift

Under the conditions of Example 2(a), 3.633 g (10 mmol) of 2-[N-(4-fluoro-3-trifluoromethylphenyl)sulfamoyl]benzoic acid, 1.536 g (10 mmol) of β-alanine ethyl ester hydrochloride, 1.531 g (10 mmol) of hydroxybenzotriazole, hydrate, as well as 1.012 g (10 mmol) of triethylamine and 2.063 g (10 mmol) of dicyclohexylcarbodiimide are reacted and worked up in analogous fashion. The crude product is chromatographed on silica gel. The title compound is eluted with ethyl acetate.

Aufarbeitung

  1. customThe crude product is chromatographed on silica gel
  2. washThe title compound is eluted with ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-58e8d20523884b67a8e827c90e18ec2b
Quelldatensatz
uspto-grants-1993_05
Patentnummer
US05210290

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