Dimethyl Sulfate → HCID 14882462, compound

Participants

Reaction Conditions

Reaction Steps

0.6 g of sodium hydride was added to a solution of 7 g (0.028 mol) of ethyl 2-chloro-4-phenylimidazole-5-carboxylate in 25 ml of dimethylformamide. Upon completion of gas evolution, 4.2 g (0.033 mol) of dimethyl sulfate was added and the mixture was heated at 80° C. for 11/2 hours. The dimethylformamide was removed under reduced pressure and the residue was poured into dilute ammonium hydroxide. After extraction with ethyl acetate, drying and removal of the solvent, chromatography on silica gel (developer: ethyl acetate/pentane) gave ethyl 2-chloro-1-methyl-4-phenylimidazole-5-carboxylate (compound no. 2.001) of m.p. 54° to 55° C.

Provenance & Evidence