HCID 14548487, compound → HCID 178444333, compound

Participants

Reaction Steps

A mixture of 0.1 mol of 4-(4-pentylcyclohex-1-enyl)-2,3-difluorobenzonitrile (prepared according to Example 1a)-1c)), 1.0 g of palladium/active carbon (1%) and 150 ml of toluene is hydrogenated to saturation at room temperature. After filtering and removing the solvent, the residue is dissolved in 150 ml of dimethyl sulfoxide, 12 g of potassium tert.-butoxide are added and the mixture is stirred at room temperature for 2 hours. Acidifying and customary working up gives 4-(trans-4-pentylcyclohexyl)-2,3-difluorobenzonitrile.

Provenance & Evidence