HCID 53677498, compound → HCID 13596549, compound

Participants

Reaction Steps

4.8 g (0.025 mol) of copper iodide was added to 10 ml of dried ether, which was cooled to -25°~-30° C. under a nitrogen gas flow and thereafter 36 ml of methyl lithium was added dropwise thereto. Then, 3.8 g (0.01 mol) of (S)-(-)-3-(p-toluenesulfonyl)-2-fluoro-2-methylpropionic acid monoethyl ester dissolved in 10 ml of dried ether at -15°~-20° C. was added dropwise thereto, which was stirred at 0°~5° C. for 10 hours. After the completion of the reaction, the precipitate was removed by filtration and then the filtrate was washed with 1 normal hydrochloric acid and further with water and dried on anhydrous magnesium sulfate. After the removal of magnesium sulfate by filtration, the solvent was distilled off and the residue as it is was used for the following reaction.

Provenance & Evidence