反应详情

In 40 ml of water is dissolved 2 g of S-(α,β-dicarboxyethyl)glutathione followed by addition of 1 g of calcium carbonate. The mixture is stirred under warming. When the evolution of carbon dioxide gas has ceased, the excess of calcium carbonate is filtered off and the filtrate is concentrated under reduced pressure. To the concentrate is added ethanol and the resulting white crystals are collected by filtration and recrystallized from water-ethanol. Thus is obtained 2.2 g of the title compound as white powdery crystals.

1. temperatureunder warming
2. filtrationthe excess of calcium carbonate is filtered off
3. concentrationthe filtrate is concentrated under reduced pressure
4. additionTo the concentrate is added ethanol
5. filtrationthe resulting white crystals are collected by filtration
6. customrecrystallized from water-ethanol