Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methylmorpholine → t-butyloxycarbonyl-L-leucyl-L-prolinamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | Isobutyl chloroformate | HCID 62365 | — |
| 반응물 | L-Leucine, N-((1,1-dimethylethoxy)carbonyl)- | HCID 83170 | — |
| 반응물 | (S)-Pyrrolidine-2-carboxamide monohydrochloride | HCID 12707183 | — |
| 반응물 | Boc-L-Phe-L-Pro-NH2 | HCID 13576349 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | t-butyloxycarbonyl-L-leucyl-L-prolinamide | HCID 7031925 | — |
반응 단계
Following the general procedure described previously for t-butyloxycarbonyl-L-phenylalanyl-L-prolinamide, a solution of t-butyloxycarbonyl-L-leucine (32.64 g), in tetrahydrofuran was activated by treatment with N-methylmorpholine (18.22 ml), followed by isobutylchloroformate (16.99 ml) at -5° C. After 15 minutes, L-prolinamide hydrochloride (15.0 g) was added as a solution in dimethylformamide, followed by N-methylmorpholine (18.22 ml) and the mixture stirred overnight at room temperature. The reaction was worked up as described previously to give the desired product, which was used for the next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05212158 |
| 출처 데이터셋 | uspto-grants-1993_05 |
| ORD ID | ord-dab328d83a3549958a7c86af4668c86e |
| 출처 메모 | uspto-grants-1993_05 |