HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Methylmorpholine → Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Methylmorpholine | HCID 7972 | — |
| Reactant | 2-Propenoic acid, 3-phenyl- | HCID 8784 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Glycine methyl ester hydrochloride | HCID 122755 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Glycine,n-(1-oxo-3-phenyl-2-propen-1-yl)-, methyl ester | HCID 582979 | — |
Reaction Steps
Cinnamic acid (38.0 g) was coupled to glycine methyl ester hydrochloride in dimethylformamide by treatment with dicyclohexylcarbodiimide (52.84 g) and 1-hydroxybenzotriazole (39.24 g), followed by N-methylmorpholine (37.56 ml). The reaction mixture was stirred overnight at room temperature and then worked up in the usual manner to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05212158 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-ecf315e47df3405c9faf417599866d90 |
| Source note | uspto-grants-1993_05 |