Oxalic Acid → HCID 67751427, compound

Participants

Reaction Steps

1.7 g of N-[2-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)ethyl]-N-[2-(2,2 -dimethylethoxy)ethyl]-N-methylamine base were dissolved in 30 ml of acetone. A solution of 0.68 g of oxalic acid in 10 ml of acetone was added to the first solution. After addition of 10 ml of n-hexane, the mixture was evaporated under reduced pressure. The residue was taken up in 10 ml of 2-butanone and n-hexane was added dropwise until the mixture became turbid. 1.96 g of N-[2-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)ethyl]-N-[2-(2,2-dimethylethoxy)ethyl]-N-methylamine oxalate having a melting point of 113°-115° were obtained.

Provenance & Evidence