Fumaric Acid → HCID 67751258, compound

Participants

Reaction Conditions

Reaction Steps

4.27 g of N-[2-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)ethyl]-N-[2-(3,4-dimethoxybenzyloxy)ethyl]-N-methylamine base were dissolved in 50 ml of tetrahydrofuran. A solution of 1.22 g of fumaric acid in 15 ml of isopropanol was added to the solution. The solution was concentrated to a volume of about 20 ml under reduced pressure, and a mixture of diethyl ether/n-hexane was added until the solution became cloudy, after which the solution was cooled to 0° C. The precipitated crystals were filtered out and dried at 50° C. 4.28 g of N-[2-((1R,3R,4S)-1-methyl-4-isopropylcyclohex-3-yloxy)et hyl]-N-[2-(3,4-dimethoxybenzyloxy)ethyl]-N-methylamine fumarate having a melting point of 72° C.-73° C. were obtained. [α]D20 =-37.0° (c=1; methanol)

Provenance & Evidence