Potassium Iodide → HCID 18651839, compound

Participants

Reaction Conditions

Reaction Steps

15 g of 5-[2-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]pentyl chloride were dissolved in 100 ml of dimethylformamide. 5.13 g of N-[2-(2,2-dimethylethoxy)ethyl]-N-methylamine (Example 12 B)), 12 g of potassium carbonate and 1 g of potassium iodide were added to the solution. The reaction mixture was stirred at a temperature of 80° C. for 12 hours. The reaction mixture was worked up by concentrating it under reduced pressure, adding 100 ml of water to the residue, and extracting the mixture three times with 80 ml portions of dichloromethane. The combined dichloromethane extracts were dried over sodium sulfate, filtered and concentrated. The crude product remaining as a residue was purified by chromatography on silica gel using dichloromethane/methanol as the eluent. 4.1 g of oily N-(5-[2-((1S,2S,5S)-6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethoxy]pent yl)-N-[2-(2,2-dimethylethoxy)ethyl]-N-methylamine were obtained.

Provenance & Evidence