Ammonia → HCID 15069926, compound

Participants

Reaction Steps

849 mg of 2-methyl6n-propyl-8alpha-ergolinylamine (3 mmol) is dissolved in 20 ml of pyridine and stirred with 2.28 ml of methoxy acetyl chloride (30 mmol) for 30 minutes at room temperature. Then it is poured onto ice, stirred for 15 minutes, make alkaline with ammonia and extracted with dichloromethane. The organic phases are dried and concentrated by evaporation. The residue is chromatographed on silica gel with ethyl acetate/methanol and crystallized from ethyl acetate. Yield 420 mg (40% of theory), [α]D =+24° (0.5% in chloroform).

Provenance & Evidence