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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 248886Generated: October 31, 2026

Methanol → HCID 70045154, compound

https://huagongshe.com/reaction/248886

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethanolHCID 887—
ReactantPotassium CarbonateHCID 11430—
Reactant2-[(2S)-1-[3-(N-benzyl-N-methylcarbamoyl)propanoyl]pyrrolidin-2-yl]-2-oxoacetic acid ethyl esterHCID 15660922—
SolventWaterHCID 962—
ProductHCID 70045154HCID 70045154150.4%

Reaction Steps

A mixture of 2-[(2S)-1-[3-(N-benzyl-N-methylcarbamoyl) propanoyl]pyrrolidin-2-yl]-2-oxoacetic acid ethyl ester (626 mg), potassium carbonate (277 mg), methanol (7 ml) and water (4 ml) was stirred for 1 hr. at room temperature. Water was added to the reaction solution. The mixture was extracted with EtOAc. The extract was washed, dried and evaporated to give the title compound (458 mg) having the following physical data:

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05212191
Source datasetuspto-grants-1993_05
ORD IDord-0f227aab2c9c40bdafdc5bb16b89119f
Source noteuspto-grants-1993_05