反应详情

Bromine in a quantity of 10.2 ml (0.2 mol) is added dropwise to a mixture of 37.8 g 3.4-dichloroacetophenone and approx. 1.0 g anhydrous AlCl3 in 600 ml dry diethylether while stirring and cooling in ice. After stirring for 0.5 hr at 0° C. and 1.5 hr at room temperature, 30 ml water are added slowly. The organic phase is separated, washed twice with water, dried and evaporated to dryness. A small amount of petroleum ether (40-60) is added to the residue and the mixture is stirred at approx. 0° C. The desired 3.4-dichlorophenacylbromide is obtained as a crystalline material in a yield of 39.8 g (74%); melting point 55°-58° C.; TLC (CH2Cl2)=0.5.

1. temperaturecooling in ice
2. stirringAfter stirring for 0.5 hr at 0° C. and 1.5 hr at room temperature
3. customThe organic phase is separated
4. washwashed twice with water
5. customdried
6. customevaporated to dryness
7. additionA small amount of petroleum ether (40-60) is added to the residue
8. stirringthe mixture is stirred at approx. 0° C