1-Butylpiperidin-4-amine dihydrochloride → N-(1-Butyl-4-piperidinyl)-4-[(4-quinolinylmethyl)amino]benzamide

HRID 248918Notes

Reaction equation

HRID 248918 reaction equation
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][NH:12][C:13]2[CH:21]=[CH:20][C:16]([C:17]([OH:19])=O)=[CH:15][CH:14]=2)=[CH:3][CH:2]=1.Cl.Cl.[NH2:24][CH:25]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][CH2:33][CH3:34])[CH2:27][CH2:26]1>>[CH2:31]([N:28]1[CH2:29][CH2:30][CH:25]([NH:24][C:17](=[O:19])[C:16]2[CH:15]=[CH:14][C:13]([NH:12][CH2:11][C:4]3[C:5]4[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=4)[N:1]=[CH:2][CH:3]=3)=[CH:21][CH:20]=2)[CH2:26][CH2:27]1)[CH2:32][CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 122628211-Butylpiperidin-4-amine dihydrochlorideHCID 197624244-[(4-Quinolinylmethyl)amino]benzoic acid

Product 1

HCID 19762437N-(1-Butyl-4-piperidinyl)-4-[(4-quinolinylmethyl)amino]benzamide

Procedure

The title compound was prepared from 4-[(4-quinolinylmethyl)amino]benzoic acid and 4-amino-1-butylpiperidine bishydrochloride by the procedure described in Example 18, m.p. 189°-190° C.

Sources & evidence

ORD record
ord-f43a22d462e94798ab17b4447a0a046a
Source dataset
uspto-grants-1993_05
Patent number
US05212182

Reaction notes

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