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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 248923Generated: October 30, 2026

Water → HCID 18946962, compound

https://huagongshe.com/reaction/248923

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantChlorosuccinimideHCID 31398—
ReactantHCID 18946596HCID 18946596—
SolventDimethylformamideHCID 6228—
ProductHCID 18946962HCID 18946962—

Reaction Steps

To a solution of methyl 2-(n-butyl)indole-7-carboxylate (P) (0.3 g) in 6 ml of dimethylformamide at room temperature was added N-chlorosuccinimide (0.17 g). The solution was stirred at room temperature for 16 hours, then water was added, and the mixture extracted with ether. The extract was separated and solvent evaporated under reduced pressure, to give methyl 2-(n-butyl)-3-chloroindole-7-carboxylate, a compound of Formula (Q) where X is chloro, as an oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05212195
Source datasetuspto-grants-1993_05
ORD IDord-eedd5e3566654d119eb69e0350119f7d
Source noteuspto-grants-1993_05