N-cyano-O-phenyl-N'-[3-(3-(piperidinomethyl)phenoxy]propyl]isourea → N-cyano-N'-[3-[N-[3-(4-fluorophenyl)-3-(2-pyridyl)propyl]-N-methylamino]propyl]-N"-[3-[3-(piperidinomethyl)phenoxy]propyl]guanidine

Participants

Reaction Steps

Preparation is effected analogously to Example 1, using 0.8 g (2.7 mmol) of N-[3-(4-fluorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,3-propanediamine and 1.04 g (2.6 mmol) of N-cyano-O-phenyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int.[%])=600 ([M+H]+ 22.4), 214 (100); IR (KBr): 2164 cm-1 (C≡N).

Provenance & Evidence