HCID 19762487, compound → HCID 178483445, compound

HRID 248949Notes

Reaction equation

HRID 248949 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH2:9][CH2:10][N:11]([CH3:19])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])=[CH:4][CH:3]=1.[C:26]([NH:28][C:29](=[N:37][CH2:38][CH2:39][S:40][CH2:41][C:42]1[N:43]=[C:44]([NH:47][C:48]([NH2:50])=[NH:49])[S:45][CH:46]=1)OC1C=CC=CC=1)#[N:27]>C(OCC)(=O)C.CO>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][N:21]=2)[CH2:9][CH2:10][N:11]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:29]([NH:28][C:26]#[N:27])=[N:37][CH2:38][CH2:39][S:40][CH2:41][C:42]2[N:43]=[C:44]([NH:47][C:48]([NH2:50])=[NH:49])[S:45][CH:46]=2)[CH3:19])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 19762487HCID 19762487, compoundHCID 178512334HCID 178512334, compound

Product 1

HCID 178483445HCID 178483445, compound

Reagents, catalysts & solvents 1

HCID 21584119Ethylacetate methanolSolvent

Procedure

Preparation is effected analogously to Example 1, using 0.5 g (1.4 mmol) of N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,6-hexanediamine and 0.52 g (1.4 mmol) of N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea as starting materials. Working up by chromatography (eluant: methylene chloride/methanol 95+5) analogously to Example 1 yields the purified title compound in the form of a dry foam; MS (+FAB method): m/z (rel. int.[%])=641 ([M+H]+, 5), 230 (47), 154 (100); IR (KBr): 2161 cm-1 (C≡N).

Workup

  1. customPreparation
  2. custompurified title compound in the form of a dry foam

Sources & evidence

ORD record
ord-e64d86c909974eff86cb175d416451ca
Source dataset
uspto-grants-1993_05
Patent number
US05212187

Reaction notes

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