1,1'-Carbonyldiimidazole → N-[5-[N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methylamino]pentyl]-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]urea

Participants

Reaction Steps

Preparation is effected analogously to Example 63, using 1.29 g (3.6 mmol) of N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,5-pentanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 1.04 g (4.2 mmol) of 3-[3-(piperidinomethyl)phenoxy]propaneamine as starting materials. Working up by chromatography (eluant: methylene chloride) analogously to Example 63 yields the purified title compound in the form of an oil; MS (+EI-80 eV): m/z (rel. int.[%])=619 ([M])+.,<1), 230 (17) 203 (100); IR (KBr): 1634 cm-1 (C≡0).

Provenance & Evidence