1,1'-Carbonyldiimidazole → HCID 19762573, compound

Participants

Reaction Steps

Preparation is effected analogously to Example 63, using 1 g (3.5 mmol) of N-[3-(4-fluorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,2-ethanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.9 g (3.6 mmol) of 3-[3-(piperidinomethyl)phenoxy]propaneamine as starting materials. Working up by chromatography (eluant: methylene chloride) analogously to Example 63 yields the purified title compound in the form of an oil; MS (EI-80 eV): m/z (rel. int.[%])=561 ([M]+., 3), 84 (70), 214 (100). For analytical purposes a sample is converted into the hydrochloride and recrystallised from ether/ethanol; m.p.: 111°-115° C.

Provenance & Evidence