1,1'-Carbonyldiimidazole → HCID 178483431, compound

Participants

Reaction Steps

Preparation is effected analogously to Example 63, using 0.6 g (1.6 mmol) of N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,8-octanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.4 g (1.7 mmol) of 2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethaneamine as starting materials. Working up by chromatography (eluant: chloroform/methanol 9+1) analogously to Example 63 yields the purified title compound in the form of a dry foam; MS (+FAB method, DMSO/MNBA): m/z (rel. int.[%])=645 ([M+H]+,<1), 234 (100); IR (KBr): 1638 cm-1 (C=O). For analytical purposes a sample is converted into the O,O'-ditoluoyltartaric acid salt and recrystallised from ether/isopropanol; m.p.: 135°-140° C.

Provenance & Evidence