1,1'-Carbonyldiimidazole → N-[2-[N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methylamino]ethyl]-N'-[2-[[(5-methylimidazol-4-yl)methyl]thio]ethyl]urea

Participants

Reaction Steps

Preparation is effected analogously to Example 63, using 0.8 g (2.6 mmol) of N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,2-ethanediamine, an equimolar amount of 1,1'-carbonyldiimidazole and 0.5 g (2.8 mmol) of 2-[[(5-methylimidazol-4-yl)methyl]thio]ethaneamine as starting materials. Working up by chromatography (eluant: ethyl acetate/methanol 9+1) analogously to Example 63 yields the purified title compound in the form of a crystalline solid; m.p.(ether): 114° C.; MS (+FAB method): m/z (rel. int.[%])=501 ([M+H]+, 15), 95 (63), 230 (100); IR (KBr): 1640 cm-1 (C=O).

Provenance & Evidence