N-cyano-O-phenyl-N'-[3-(3-(piperidinomethyl)phenoxy]propyl]isourea → HCID 54107872, compound

Participants

Reaction Steps

Preparation is effected analogously to Example 1, using 0.52 g (1.6 mmol) of N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,3-propanediamine and the equimolar amount of N-cyano-O-phenyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a viscous oil which crystallises from absolute ether at -20° C.; MS (+FAB method): m/z (rel. int. [%])=627 ([M+H]+, 6), 241 (11), 121 (100); IR (KBr): 2165 cm-1 (C≡N); m.p.: 62°-65° C. (ether).

Provenance & Evidence