HRID24898

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

HCID225544

2-bromo-n,n-dimethylacetamide

C4H8BrNO

HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

$结构：CC(=O)N1C(=O)/C(=C(\Nc2ccc(NS(=O)(=O)c3ccccc3)cc2)c2ccccc2)c2ccccc21$

HCID178473950

未命名化合物

PRODUCTS

生成物

$结构：CN(C)C(=O)CN(c1ccc(N/C(=C2\C(=O)Nc3ccccc32)c2ccccc2)cc1)S(=O)(=O)c1ccccc1$

HCID178484609

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Prepared analogously to Examples 1 and 187 from (Z)-1-acetyl-3-[1-(4-phenylsulphonylamino-phenylamino)-1-phenyl-methylidene]-2-indolinone, bromoacetic acid-N,N-dimethylamide and potassium tert.butoxide in DMSO and subsequent treatment with sodium hydroxide solution in methanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-02afeb980c7546138e3fb3309bccacd2
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)/[C:6](=[C:13](/[NH:20][C:21]2[CH:26]=[CH:25][C:24]([NH:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])=[CH:23][CH:22]=2)\[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)/[C:5]1=[O:37])(=O)C.[CH3:38][N:39]([CH3:44])[C:40](=[O:43])[CH2:41]Br.CC(C)([O-])C.[K+].[OH-].[Na+]>CS(C)=O.CO>[CH3:38][N:39]([CH3:44])[C:40]([CH2:41][N:27]([C:24]1[CH:25]=[CH:26][C:21]([NH:20]/[C:13](=[C:6]2\[C:5](=[O:37])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[CH:10][CH:11]=3)/[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:22][CH:23]=1)[S:28]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)(=[O:29])=[O:30])=[O:43]