Sodium Hydroxide → HCID 178484609, compound

HRID 24898Notes

Reaction equation

HRID 24898 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)/[C:6](=[C:13](/[NH:20][C:21]2[CH:26]=[CH:25][C:24]([NH:27][S:28]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=3)(=[O:30])=[O:29])=[CH:23][CH:22]=2)\[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)/[C:5]1=[O:37])(=O)C.[CH3:38][N:39]([CH3:44])[C:40](=[O:43])[CH2:41]Br.CC(C)([O-])C.[K+].[OH-].[Na+]>CS(C)=O.CO>[CH3:38][N:39]([CH3:44])[C:40]([CH2:41][N:27]([C:24]1[CH:25]=[CH:26][C:21]([NH:20]/[C:13](=[C:6]2\[C:5](=[O:37])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[CH:10][CH:11]=3)/[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:22][CH:23]=1)[S:28]([C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)(=[O:29])=[O:30])=[O:43]

Participants

7

Reactant 4

HCID 14798Sodium HydroxideHCID 2255442-Bromo-N,N-dimethylacetamideHCID 23665647Potassium tert-butoxideHCID 178473950HCID 178473950, compound

Product 1

HCID 178484609HCID 178484609, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 887MethanolSolvent

Procedure

Prepared analogously to Examples 1 and 187 from (Z)-1-acetyl-3-[1-(4-phenylsulphonylamino-phenylamino)-1-phenyl-methylidene]-2-indolinone, bromoacetic acid-N,N-dimethylamide and potassium tert.butoxide in DMSO and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-02afeb980c7546138e3fb3309bccacd2
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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