反应详情

Preparation is effected analogously to Example 1, using 0.54 g (1.6 mmol) of N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,5-pentanediamine and the equimolar amount of N-cyano-O-phenyl-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int. %]) =643 ([M+H]+, 7), 229 (54), 154 ([m-NO2 -benzylOH] 100); IR (KBr): 2165 cm-1 (C≡N). For further analysis, a portion of the compound is converted into the tartaric acid salt which forms a dry foam under reduced pressure.

1. customPreparation
2. customWorking up by chromatography analogously to Example 1 yields the
3. custompurified title compound in the form of a viscous oil