1,1'-Carbonyldiimidazole → N-[6-[N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methylamino]hexyl]-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]urea

Participants

Reaction Steps

Preparation is effected analogously to Example 63, using 0.58 g (1.5 mmol) of N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,6-hexanediamine and the equimolar amounts of 1,1'-carbonyldiimidazole and 3-[3-(piperidinomethyl)phenoxy]propylamine as starting materials. Working up by chromatography analogously to Example 63 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int. [%])=645 ([M+H]+, 8), 121 (100); IR (KBr): 1635 cm-1 (C=O). For further analysis, a portion of the compound is converted into the tartaric acid salt in an ethanol/ether solvent mixture; m.p.: 75° C. (ethanol/ether).

Provenance & Evidence