Sodium Hydroxide → HCID 178427471, compound

HRID 24899Notes

Reaction equation

HRID 24899 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)/[C:6](=[C:13](/[NH:20][C:21]2[CH:26]=[CH:25][C:24]([NH:27][S:28]([C:31]3[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=3)(=[O:30])=[O:29])=[CH:23][CH:22]=2)\[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)/[C:5]1=[O:38])(=O)C.[CH3:39][N:40]([CH3:45])[C:41](=[O:44])[CH2:42]Br.CC(C)([O-])C.[K+].[OH-].[Na+]>CS(C)=O.CO>[CH3:39][N:40]([CH3:45])[C:41]([CH2:42][N:27]([C:24]1[CH:23]=[CH:22][C:21]([NH:20]/[C:13](=[C:6]2\[C:5](=[O:38])[NH:4][C:12]3[C:7]\2=[CH:8][CH:9]=[CH:10][CH:11]=3)/[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[CH:26][CH:25]=1)[S:28]([C:31]1[CH:32]=[CH:33][C:34]([CH3:37])=[CH:35][CH:36]=1)(=[O:29])=[O:30])=[O:44]

Participants

7

Reactant 4

HCID 14798Sodium HydroxideHCID 2255442-Bromo-N,N-dimethylacetamideHCID 23665647Potassium tert-butoxideHCID 178473952HCID 178473952, compound

Product 1

HCID 178427471HCID 178427471, compound

Reagents, catalysts & solvents 2

HCID 679Dimethyl SulfoxideSolventHCID 887MethanolSolvent

Procedure

Prepared analogously to Examples 1 and 187 from (Z)-1-acetyl-3-{1-[4-(p-tolylsulphonylamino)-phenylamino]-1-phenyl-methylidene}-2-indolinone, bromoacetic acid-N,N-dimethylamide and potassium tert.butoxide in DMSO and subsequent treatment with sodium hydroxide solution in methanol.

Sources & evidence

ORD record
ord-621912ff7ea141ce8b2c896c8398afe3
Source dataset
uspto-grants-2005_02
Patent number
US06855710B2

Reaction notes

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