Acetic Anhydride → 3-Methyl-4-acetylamino-N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-N-(3-methoxyphenyl)benzamide
Reaction equation
[NH2:1][C:2]1[CH:35]=[CH:34][C:5]([C:6]([N:8]([CH2:17][CH2:18][N:19]2[CH2:24][CH2:23][CH:22]([C:25](=[O:33])[C:26]3[CH:31]=[CH:30][C:29]([F:32])=[CH:28][CH:27]=3)[CH2:21][CH2:20]2)[C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=2)=[O:7])=[CH:4][C:3]=1[CH3:36].[C:37](OC(=O)C)(=[O:39])[CH3:38]>>[CH3:36][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][C:2]=1[NH:1][C:37](=[O:39])[CH3:38])[C:6]([N:8]([CH2:17][CH2:18][N:19]1[CH2:24][CH2:23][CH:22]([C:25](=[O:33])[C:26]2[CH:27]=[CH:28][C:29]([F:32])=[CH:30][CH:31]=2)[CH2:21][CH2:20]1)[C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([O:15][CH3:16])[CH:10]=1)=[O:7]Participants
3
Procedure
Using 4-amino-3-methyl-N-{2-[4-(4-fluorobenzoyl)piperidino]-ethyl}-N-(3-methoxyphenyl)benzamide (489.0 mg, 1.00 mmol) and acetic anhydride (0.19 ml, 2.00 mmol), the procedure of Inventive Example 94 was repeated to obtain 474.0 mg (89.3%) of the title compound in a colorless amorphous form.
Sources & evidence
- ORD record
- ord-7176200d5bd54428a5b4fbfba85f6255
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05728835
Reaction notes
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