HCID 19762492, compound → HCID 178491105, compound

HRID 249000Notes

Reaction equation

HRID 249000 reaction equation
[CH3:1][O:2][C:3]1[CH:24]=[CH:23][C:6]([CH2:7][N:8]([CH2:15][CH2:16][N:17]([CH3:22])[CH2:18][CH2:19][CH2:20][NH2:21])[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=2)=[CH:5][CH:4]=1.[C:25]([NH:27][C:28](=[N:36][CH2:37][CH2:38][S:39][CH2:40][C:41]1[N:42]=[C:43]([NH:46][C:47]([NH2:49])=[NH:48])[S:44][CH:45]=1)OC1C=CC=CC=1)#[N:26]>>[C:25]([NH:27][C:28]([NH:36][CH2:37][CH2:38][S:39][CH2:40][C:41]1[N:42]=[C:43]([NH:46][C:47]([NH2:49])=[NH:48])[S:44][CH:45]=1)=[N:21][CH2:20][CH2:19][CH2:18][N:17]([CH2:16][CH2:15][N:8]([CH2:7][C:6]1[CH:23]=[CH:24][C:3]([O:2][CH3:1])=[CH:4][CH:5]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N:10]=1)[CH3:22])#[N:26]

Participants

3

Reactant 2

HCID 19762492HCID 19762492, compoundHCID 178512334HCID 178512334, compound

Product 1

HCID 178491105HCID 178491105, compound

Procedure

Preparation is effected analogously to Example 1, using 0.52 g (1.6 mmol) of N-[2-[N-(4-methoxybenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,3-propanediamine and the equimolar amount of N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea as starting materials. Chromatographic working-up analogously to Example 1 yields the purified title compound in the form of a viscous oil that crystallises from ether at -20° C.; MS (+FAB method): m/z (rel. int. [%])=610 ([M+H]+, 1), 121 (100); IR (KBr): 2161 cm-1 (C≡N); m.p.: 54° C. (ether).

Workup

  1. customPreparation
  2. customyields the
  3. custompurified title compound in the form of a viscous oil
  4. customthat crystallises from ether at -20° C.

Sources & evidence

ORD record
ord-9d3f1735547f40ce9019d198e44a38e0
Source dataset
uspto-grants-1993_05
Patent number
US05212187

Reaction notes

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