HCID 19762513, compound → HCID 178484313, compound

HRID 249003Notes

Reaction equation

HRID 249003 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]([CH2:14][CH2:15][N:16]([CH3:20])[CH2:17][CH2:18][NH2:19])[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1.[C:23]([NH:25][C:26](=[N:34][CH2:35][CH2:36][S:37][CH2:38][C:39]1[N:40]=[C:41]([NH:44][C:45]([NH2:47])=[NH:46])[S:42][CH:43]=1)OC1C=CC=CC=1)#[N:24]>>[C:23]([NH:25][C:26]([NH:19][CH2:18][CH2:17][N:16]([CH2:15][CH2:14][N:7]([CH2:6][C:5]1[CH:21]=[CH:22][C:2]([F:1])=[CH:3][CH:4]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[CH3:20])=[N:34][CH2:35][CH2:36][S:37][CH2:38][C:39]1[N:40]=[C:41]([NH:44][C:45]([NH2:47])=[NH:46])[S:42][CH:43]=1)#[N:24]

Participants

3

Reactant 2

HCID 19762513HCID 19762513, compoundHCID 178512334HCID 178512334, compound

Product 1

HCID 178484313HCID 178484313, compound

Procedure

Preparation is effected analogously to Example 1, using 0.30 g (1.0 mmol) of N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,2-ethanediamine and the equimolar amount of N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int. [%])=584 ([M+H]+, 3), 109 (100); IR (KBr): 2165 cm-1 (C≡N). For further analysis, a portion of the compound is converted into the tartaric acid salt and recrystalised from isopropanol/ether; m.p.: 109° C. (isopropanol/ether).

Workup

  1. customPreparation
  2. customWorking up by chromatography analogously to Example 1 yields the
  3. custompurified title compound in the form of a viscous oil
  4. customrecrystalised from isopropanol/ether

Sources & evidence

ORD record
ord-65be5a1bf38442ada3a1653d041b8d56
Source dataset
uspto-grants-1993_05
Patent number
US05212187

Reaction notes

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