HCID 19762527, compound → HCID 178483467, compound

Participants

Reaction Steps

Preparation is effected analogously to Example 1, using 0.51 g (1.5 mmol) of N-[2-[N-(4-fluorobenzyl)-N-(2-pyridyl)amino]ethyl]-N-methyl-1,5-pentanediamine and the equimolar amount of N-cyano-N'-[2-[[(2-guanidino-4-thiazolyl)methyl]thio]ethyl]-O-phenyl-isourea as starting materials. Working up by chromatography analogously to Example 1 yields the purified title compound in the form of a viscous oil; MS (+FAB method): m/z (rel. int. [%])=626 ([M+H]+, 3), 154 ([m-NO2 benzylOH] 100); IR (KBr): 2162 cm- (C≡N). For further analysis, a portion of the compound is converted into the tartaric acid salt and recrystallised from isopropanol/petroleum ether; m.p.: 103° C. (isopropanol/petroleum ether).

Provenance & Evidence