HRID24902

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

HCID225544

2-bromo-n,n-dimethylacetamide

C4H8BrNO

HCID23665647

2-Methyl-2-propanol, potassium salt

C4H9KO

$结构：CC(=O)N1C(=O)/C(=C(\Nc2ccc(NS(=O)(=O)c3ccc(C)cc3)cc2)c2ccccc2)c2cc([N+](=O)[O-])ccc21$

HCID178473953

未命名化合物

PRODUCTS

生成物

$结构：Cc1ccc(S(=O)(=O)N(CC(=O)N(C)C)c2ccc(N/C(=C3\C(=O)Nc4ccc([N+](=O)[O-])cc43)c3ccccc3)cc2)cc1$

HCID178427472

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID679

Dimethyl sulfoxide

C2H6OS

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Prepared analogously to Examples 82 and 187 from (Z)-1-acetyl-3-{1-[4-(p-tolylsulphonylamino)-phenylamino]-1-phenyl-methylidene}-5-nitro-2-indolinone, bromoacetic acid-N,N-dimethylamide and potassium tert.butoxide in DMSO and subsequent treatment with sodium hydroxide solution in methanol.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be67a9f166cc40a6bc7d98a3d68a96a4
来源数据集: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06855710B2
来源说明: uspto-grants-2005_02

反应 SMILES

C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=2)/[C:6](=[C:16](/[NH:23][C:24]2[CH:29]=[CH:28][C:27]([NH:30][S:31]([C:34]3[CH:39]=[CH:38][C:37]([CH3:40])=[CH:36][CH:35]=3)(=[O:33])=[O:32])=[CH:26][CH:25]=2)\[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)/[C:5]1=[O:41])(=O)C.[CH3:42][N:43]([CH3:48])[C:44](=[O:47])[CH2:45]Br.CC(C)([O-])C.[K+].[OH-].[Na+]>CS(C)=O.CO>[CH3:42][N:43]([CH3:48])[C:44]([CH2:45][N:30]([C:27]1[CH:28]=[CH:29][C:24]([NH:23]/[C:16](=[C:6]2\[C:5](=[O:41])[NH:4][C:12]3[C:7]\2=[CH:8][C:9]([N+:13]([O-:15])=[O:14])=[CH:10][CH:11]=3)/[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)=[CH:25][CH:26]=1)[S:31]([C:34]1[CH:35]=[CH:36][C:37]([CH3:40])=[CH:38][CH:39]=1)(=[O:33])=[O:32])=[O:47]