HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,7-heptanediamine → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,7-heptanediamine | HCID 19762535 | — |
| Reactant | Ethylacetate methanol | HCID 21584119 | — |
| Reactant | 1-Methylthio-1-[3-[3-(piperidinomethyl)phenoxy]propyl]amino-2-nitroethene | HCID 67882093 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ammonia | HCID 222 | — |
| Product | N-[7-[N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methylamino]heptyl]-N'-[3-[3-(piperidinomethyl)phenoxy]propyl]-2-nitro-1,1-ethenediamine | HCID 67882071 | — |
Reaction Steps
A mixture of 0.73 g (1.9 mmol) of N-[3-(4-chlorophenyl)-3-(2-pyridyl)propyl]-N-methyl-1,7-heptanediamine and an equimolar amount of 1-methylthio-1-[3-[3-(piperidinomethyl)phenoxy]propyl]amino-2-nitro-ethene is heated under reflux for 12 hours in 20 ml of acetonitrile. The batch is then freed of solvent and the title compound is isolated in the form of a viscous oil by means of preparative thick-layer chromatography (eluant: ethyl acetate/methanol 9+1, ammonia atmosphere); MS (+FAB method): m/z (rel. int. [%])=691 ([M+H]30 12), 230 (100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05212187 |
| Source dataset | uspto-grants-1993_05 |
| ORD ID | ord-4626132b314748ffb6e6454d5c025e81 |
| Source note | uspto-grants-1993_05 |