Triethylamine → 1-(2-(3(R)-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(methylsulfonyloxy)propyl)phenyl)ethanone

Participants

Reaction Conditions

Reaction Steps

At -40° C., methanesulfonyl chloride (1.25 mL, 16.2 mmol) and Et3N (2.8 mL, 20 mmol) were added successively to a solution of the hydroxyketone of Step 4 (6.157 g, 13.44 mmol) in 135 mL of CH2Cl2 and the mixture was stirred at -40° C. for 30 min., then at 0° C. for an hour. A saturated solution of NaHCO3 was added and the title mesylate was extracted into CH2CL2, dried over Na2SO4, concentrated and the remaining traces of water were co-evaporated twice with toluene. This mesylate was used as such in Step 7.

Provenance & Evidence