化工社化工社 化学情報印刷レポート · 研究参考用
Ammonia → 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ammonia | HCID 222 | — |
| 反応物 | N-(6-chloro-7H-purin-2-yl)acetamide | HCID 6098997 | — |
| 反応物 | 2,3,5-tri-O-acetyl-beta-D-ribofuranosylpurine | HCID 69884339 | — |
| 触媒 | Mercurous Chloride | HCID 24182 | — |
| 生成物 | 2-amino-6-chloro-9-(beta-D-xylofuranosyl)purine | HCID 14284102 | — |
反応手順
The chloromercury derivative of 2-acetamido-6-chloropurine is condensed with 2,3,5-tri-O-acetyl-β-D-ribofuranosylpurine utilizing the method of Lee et. al. (1971), J. Med. Chem., 14:819. The condensation product was treated with ammonia to yield 2-amino-6-chloro-9-(β-D-xylofuranosyl)purine. Further treatment with sodium hydroxyethylmercaptide gives the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05212295 |
| 出典データセット | uspto-grants-1993_05 |
| ORD ID | ord-c337ce6791bb4561b9d6b1749ed0dbdb |
| 出典メモ | uspto-grants-1993_05 |