Pyridine → HCID 136342781, compound

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Reaction Steps

A mixture of 1,2-dihydro-6-methyl-2-oxo-5-(1-oxopentyl)-3-pyridinecarbonitrile (0.70 g, 0.0032 mol), methoxyamine hydrochloride (0.32 g, 0.0038 mol) and pyridine (2.0 ml) was heated and stirred at reflux in EtOH (30 ml) overnight. The solution was cooled to room temperature and concentrated on the rotary evaporator. The residue was diluted with H2O and the resulting solid collected by filtration. Recrystallization (MeOH-H2O) gave 0.38 g (48%) m.pt. 159-161.

Provenance & Evidence