反应详情

温度

0 °C

Propionyl chloride (13.0 ml) was added to a suspension of aluminum chloride (20.0 g) in dichloromethane (200 ml) at 0° C. After the mixture was stirred at 0° C. for 1 hour, isobutylbenzene (23.6 ml) was added to the mixture. The mixture was stirred at 0° C. for 2 hours and poured into ice water. The organic layer was washed with water, dried over magnesium sulfate and evaporated. The residual oil was distilled under reduced pressure to give 4'-isobutylpropiophenone as a colourless oil (24.4 g).

1. stirringThe mixture was stirred at 0° C. for 2 hours
2. washThe organic layer was washed with water
3. dry with materialdried over magnesium sulfate
4. customevaporated
5. distillationThe residual oil was distilled under reduced pressure