Benzyl 4-[3-(3-nitrobenzyl)indol-1-yl]-4-oxobutyrate → 4-[3-(3-Aminobenzyl)indol-1-yl]-4-oxobutyric acid

Participants

Reaction Conditions

Reaction Steps

To a solution of benzyl 4-[3-(3-nitrobenzyl)indol-1-yl]-4-oxobutyrate (320 mg) in a mixture of 1,4-dioxane (6 ml) and methanol (3 ml) was added 10% palladium on activated carbon (60 mg), and the mixture was shaken under hydrogen atmosphere (3 atm) at 25° C. for 1.5 hours. The catalyst was filtered off and the filtrate was evaporated. The crude crystals were washed with hot chloroform and hot ethyl acetate to give 4-[3-(3-aminobenzyl)indol-1-yl]-4-oxobutyric acid (157 mg).

Provenance & Evidence