HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Nitrophenylmethyl)-thiomorpholine-1-oxide → 4-(4-Aminophenylmethyl)-thiomorpholine-1-oxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Nitrophenylmethyl)-thiomorpholine-1-oxide | HCID 22569427 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-Aminophenylmethyl)-thiomorpholine-1-oxide | HCID 22569471 | — |
Reaction Steps
1.2 g of Raney nickel are added to a solution of 3.9 g (15 mmol) of 4-(4-nitrophenylmethyl)-thiomorpholine-1-oxide in 10 ml of dichloromethane and 40 ml of methanol. The mixture is hydrogenated under a hydrogen atmosphere. The product is obtained by chromatography on silica gel (dichloromethane/methanol=9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06855710B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-5100a5120f0944329eaaa65ceb44c7b3 |
| Source note | uspto-grants-2005_02 |